Aston Villa returned to winning ways in stunning fashion as Ollie Watkins scored twice in a 3-0 away thumping of an abject Arsenal in drizzly north London on Sunday.
Paris St Germain will play Borussia Dortmund and Barcelona were pitted against an unpredictable Napoli, while Chelsea were drawn against Bayern Munich. City, who will be at home in the second leg, have yet to beat the Spanish side with two draws and two defeats in their previous four meetings.
Ten-man Arsenal suffered a 3-0 Premier League defeat at Leicester City on Sunday in another blow to their hopes of finishing in the top four and qualifying for the Champions League.
A round-up of Saturday's action in the Premier League.
Spaniard Herrera finished off a fine move with a precise header from Pogba's cross just past the half-hour and United's French midfielder scored himself when he nodded powerfully home from a Marcus Rashford delivery before the break.
Wayne Rooney made history by equalling Bobby Charlton's Manchester United record and becoming the club's leading all-time goalscorer after netting his 249th goal (543 matches) during an FA Cup match against Reading on Saturday.
Reigning champions Manchester City took the lead after 24 seconds but suffered a shock 2-1 defeat at Newcastle United.
Liverpool's Sadio Mane marked his return from injury with a late goal to break Norwich City's resistance and secure a 1-0 win on Saturday to extend his side's Premier League lead to 25 points.
Images from the English Premier League matches played on Saturday
Manchester United battled back from two goals down to beat Newcastle United 3-2 at Old Trafford on Saturday as a 90th-minute winner from Alexis Sanchez completed a spirited comeback to ease the pressure on manager Jose Mourinho.
High drama ensued during the English Premier League matches on Wednesday as Spurs manager Jose Mourinho was booked while Brighton stunned Chelsea via Alireza Jahanbakhsh's superb equaliser to deny the Blues victory. Here is all the EPL action in IMAGES from Wednesday's matches.
Manchester City needed a second-half penalty from striker Erling Haaland to break the resistance of a dogged Crystal Palace.
A round-up of Saturday's action in the Premier League.
Images from Sunday's Premier League action.
A round-up of Saturday's action in the Premier League.
Spurs Premier League match at Brighton postponed due to COVID-19
Manchester City endured some anxious moments but escaped from fourth-tier Newport County with their FA Cup hopes intact as Phil Foden scored twice in an ultimately comfortable 4-1 fifth-round victory on Saturday.
Included in Barcelona squad to face Dortmund
A rejuvenated Manchester United claimed a sixth win from six matches since former striker Ole Gunnar Solskjaer stepped in following the sacking of Jose Mourinho.
Manchester City suffered their first home Premier League loss in eight months as a shock 3-2 defeat by Crystal Palace on Saturday left Pep Guardiola's champions trailing leaders Liverpool by four points.
Real Madrid coach Zinedine Zidane said he was disappointed that he was only asked about the referee's decisions after his side earned a 2-1 victory at Real Sociedad on Sunday to climb above Barcelona and top La Liga.
Chelsea brought a whole new dimension to the Premier League title race when they handed Manchester City their first defeat of the season on Saturday to leave Mohamed Salah-inspired Liverpool as the new leaders.
News of all that transpired on and off the football field.
The 41-year-old has made 640 appearances in Serie A, within striking distance of the 647-game record of AC Milan defender Paolo Maldini. Buffon began his career at Parma before moving to the Turin club in 2001.
Manchester City thrashed Southampton 6-1 to remain top of the Premier League.
News of all that's transpired on and off the football field
News of all that's transpired on and off the football field
'So, the Champions League final will be played between two teams who just don't know when they are beaten,' says Suhit K Sen.
Here are talking points from the weekend's Premier League action:
English Premier League matches have continued behind closed doors during the second lockdown announced on November 1. Supporters have not been allowed into sporting venues since the first lockdown was announced in March, barring a few exceptions.
Real Madrid goalkeeper Keylor Navas says the signing of Belgium keeper Thibaut Courtois has not affected his desire to remain at the triple European champions as he emphatically ruled out leaving the club in order to be assured of first team football.
Having enjoyed plenty of success at Old Trafford as Alex Ferguson's trusted right-hand man, the chance to return after a six year absence was not an opportunity the 56-year-old was going to let pass.
News of all that's transpired on and off the football field
News of all that's transpired on and off the football field
Manchester City overcame a spirited Bournemouth side 3-1 on Saturday to maintain their unbeaten streak and extend their lead at the top of the English Premier League to five points.
Messi, whose deal expires in 2021, had called his side "weak" and "inconsistent" after they lost the league title to Real Madrid.
The pain of missing out on a first domestic league crown for 29 years will be eased by the knowledge that European glory could be on the horizon for Liverpool
IMAGES from the English Premier League matches played on Wednesday.
Unai Emery's side were heading for a demoralising defeat, three days after losing meekly to Sheffield United in the Premier League, but substitute Pepe's late intervention kept the Gunners top of Group F with a maximum nine points.
Manchester City claimed the win required to finally end Liverpool's relentless attempt to dethrone them as Premier League champions as they hit back from a goal down to crush Brighton and Hove Albion on the south coast on Sunday.
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